MIT Department of Electrical Engineering & Computer Science

E E C S

Bio-Labs on a Chip: An Explosion of New Directions for Microfabrication

D. Jed Harrison
University of Alberta, Edmonton, Alberta, Canada

Monday, March 10, 1997
4:00 PM (3:45 refreshments)
Edgerton Hall, Room 34-101
EECS Colloquium

Abstract

Microflow systems etched in glass substrates provide a network in which chemical reactions, sample injection and separation of reaction products can be achieved. Electroosmotic or electrophoretic pumping can be used to deliver sample and reagents, providing both mass transport and separation. This technique uses 1-15 kV to control fluid flow, without a need for pumps or valves.

A variety of chemical reaction and separation processes can be performed on-chip. The presentation illustrates the range of applications, the nature of the chemistry which can be driven on-chip, and the fluid mechanics issues associated with electrically driven, multi-flow channel manifolds. Clinically relevant immunological assays for proteins, reactions of oligonucleotide probes and manipulation of Biological cells will be presented. Together, these results illustrate the potential of the lab-on-a-chip concept.


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Created: Feb 5, 1997  | Modified: Jun 24, 1997
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